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Case Study
- Micronodular Thymoma with Lymphoid Stroma in a Multilocular Thymic Cyst: A Case Study
- Na Rae Kim, Jae Ik Lee, Seung Yeon Ha
- Korean J Pathol. 2013;47(4):392-394. Published online August 26, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.392
- 7,060 View
- 70 Download
- 12 Crossref
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Abstract
PDF Herein, we report a case of micronodular thymoma with lymphoid stroma in a previously healthy 73-year-old male. Thymectomy was performed. The solid and macrocystic masses were encapsulated with focal invasion. The solid portion consisted of nodules of bland-looking spindle or round epithelial cells in lymphoid stroma containing prominent germinal centers. The epithelial cells had moderate amount of cytoplasm and occasional mucin production. The cystic portion was lined with cuboidal epithelium. According to World Health Organization (WHO) classification, the mass was diagnosed as a micronodular thymoma with lymphoid stroma accompanied by a pre-existing multilocular thymic cyst. Micronodular thymoma with lymphoid stroma, a possible variant of type A thymoma, is an extremely rare tumor. This so-called "unusual" variant may imply the schematic weakness of the current WHO classification that cannot cover all morphologic types. Further study is recommended for clarification of this variant and its incorporation into the current classification.
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Citations
Citations to this article as recorded by
- GTF2Imutation in micronodular thymoma with lymphoid stroma
Andrea Bille, Katherine Fryer, Andrew Wallace, Daisuke Nonaka
Journal of Clinical Pathology.2024; 77(2): 125. CrossRef - Thymic epithelial tumours: histopathological classification and differential diagnosis
Jan von der Thüsen
Histopathology.2024; 84(1): 196. CrossRef - Micronodular Thymomas With Prominent Cystic Changes: A Clinicopathological and Immunohistochemical Study of 25 Cases
Diana M. Oramas, Cesar A. Moran
International Journal of Surgical Pathology.2021; 29(4): 352. CrossRef - Two cases of resection of micronodular thymoma with lymphoid stroma
Seiji Omura, Kyohei Masai, Kaoru Kaseda, Keisuke Asakura, Tomoyuki Hishida, Hisao Asamura
The Journal of the Japanese Association for Chest Surgery.2021; 35(6): 705. CrossRef - Two surgical cases of micronodular thymoma with lymphoid stroma
Yusuke Kita, Yoshimasa Tokunaga, Taku Okamoto
The Journal of the Japanese Association for Chest Surgery.2020; 34(2): 166. CrossRef - Thoracoscopic Thymectomy for Large Thymic Cyst: Myasthenia Gravis With Thymoma Concealed by Thymic Cyst
Motoki Yano, Hiroki Numanami, Takashi Akiyama, Rumiko Taguchi, Chihiro Furuta, Akari Iwakoshi, Masayuki Haniuda
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(3): e34. CrossRef - A resected case of micronodular thymoma with lympoid stroma
Hiromitsu Domen, Yasuhiro Hida, Yasunari Takakuwa, Yuki Iijima, Kazuomi Ichinokawa, Hidehisa Yamada
The Journal of the Japanese Association for Chest Surgery.2019; 33(5): 504. CrossRef - Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases
Xuxia Shen, Yan Jin, Lei Shen, Yihua Sun, Haiquan Chen, Yuan Li
Diagnostic Pathology.2018;[Epub] CrossRef - Micronodular thymoma with lymphoid stroma: Two cases, one in a multilocular thymic cyst, and literature review
Linlin Qu, Yan Xiong, Qian Yao, Bo Zhang, Ting Li
Thoracic Cancer.2017; 8(6): 734. CrossRef - Cystic Micronodular Thymoma. Report of a Case
Mlika M
Journal of Clinical, Medical and Experimental Images.2017; 1(1): 001. CrossRef - A Rare Case of Mixed Type A Thymoma and Micronodular Thymoma with Lymphoid Stroma
Yoon Jin Cha, Joungho Han, Jimin Kim, Kyung Soo Lee, Young Mog Shim
Journal of Pathology and Translational Medicine.2015; 49(1): 75. CrossRef - Micronodular thymic neoplasms: case series and literature review with emphasis on the spectrum of differentiation
Wadad S Mneimneh, Yesim Gökmen-Polar, Kenneth A Kesler, Patrick J Loehrer Sr, Sunil Badve
Modern Pathology.2015; 28(11): 1415. CrossRef
- GTF2Imutation in micronodular thymoma with lymphoid stroma
Case Report
- The Fine Needle Aspiration Cytology of a Metastatic Pulmonary Adrenocortical Carcinoma Mimicking Primary Large Cell Carcinoma of the Lung.
- Na Rae Kim, Dong Hae Chung, Jae Ik Lee, Seung Yeon Ha
- Korean J Pathol. 2010;44(5):558-563.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.558
- 2,665 View
- 13 Download
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Abstract
PDF
- Adrenocortical carcinoma is a rare neoplasm and it has an invariably lethal prognosis. We report here on the fine needle aspiration cytologic findings of a solitary metastatic pulmonary adrenocortical carcinoma in a 24-year-old woman. The aspirate smears were very cellular and they were composed of a monomorphic population of large polyhedral cells with abundant granular or vacuolated cytoplasm, and the cells were predominantly singly scattered in a necrotic background. Multinucleated pleomorphic tumor cells were also found. Pleomorphic nuclei with thickened nuclear membranes were impinging on the cell membranes. Mitotic activity was occasionally seen. The cytologic findings of pleomorphic cells with microvacuolated cytoplasm and the presence of vague gland-like sheets, as well as the patient's history of undergoing adrenalectomy for primary adrenocortical carcinoma helped the pathologist reach the diagnosis of metastatic adrenocortical carcinoma. Here, we focus on the cytologic differential points of metastastic pulmonary adrenocortical carcinoma and primary pulmonary carcinoma, especially large cell carcinoma.
Original Article
- Significance of Circumferential Resection Margin Involvement Following Esophagectomy for Esophageal Cancer.
- Mee Sook Roh, Jae Ik Lee, Phil Jo Choi
- Korean J Pathol. 2004;38(1):23-28.
- 1,530 View
- 14 Download
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Abstract
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- BACKGROUND
This study was performed to examine the significance of the circumferential resection margin (CRM) involvement by a tumor on the postoperative survival after esophageal cancer surgery.
METHODS
Fifty nine resected cases of esophageal cancers were retrospectively reviewed. The presence of a tumor either at, or within 1 mm of, the CRM was recorded. By an immunohistochemical study for Ki-67, the Ki-67 differential grades (Ki-67 DG) were defined according to the differences between the Ki-67 labeling indices of the central and of peripheral areas of the tumor nearest to the CRM: Ki-67 DG 0 (< or =10%) and Ki-67 DG 1 (>10%). The CRM involvement was correlated with the clinicopathological factors, Ki-67 DG and survival data.
RESULTS
CRM involvement was found in 26 (44.1%) of the 59 cases. There were significant differences in the cases, both with and without CRM involvement of tumor cells, in relation to lymph node metastasis, lymphovascular, perineural invasions and tumor stage (p<0.05). Ten (38.3%) of the 26 with, and 3 (9.1%) of 33 cases without, CRM involvement, showed Ki-67 DG 1 (p=0.007). The 3-year survivals of patients with and without CRM involvement were 26.8 and 61.8%, respectively (p=0.003).
CONCLUSIONS
These results show that the CRM involvement status may be used as a predictor of survival after esophageal cancer surgery, and CRM involvement is more an indicator of an advanced disease than of an incomplete resection.
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